A study at the Columbia University Medical Center has discovered that the tau protein, thought to be largely responsible for the condition of Alzheimer’s disease in the human brain, travels along neurons and is able to jump from cell to cell.
The research was done using transgenic mice which has worked as an effective model in previous studies. As a result of these findings, some researchers suggest that they key to treating both early onset and later variant Alzheimer’s will be to identify and isolate the illness as early as possible. In other words, identify the location of the tau proteins and then target them for treatment.
In this way, Alzheimer’s treatment may become similar to cancer treatment which aims to identify the location of the tumor and either excise or radiate it in order to remove the disease. Just as in healing carcinomas, the key is to eliminate the threat before the metastasis which involved spreading to other parts of the body.
Previous studies have also shown that the fibrous tangles of tau proteins often begin in the entorhinal cortex. This makes sense from an anatomical perspective as it is this area of the brain that is responsible for processing memories.
As the disease progresses, higher functioning brain cortices are involved which ultimately leads to the fatal nature of the disease. So, in the future we may see that Alzheimer’s disease is treated and cured by simply treating this one small area of the brain. Further research will of course be continued, but the early results are filled with promise.