Study Finds Alzheimers Grows Like Infection

A study at the Columbia University Medical Center has discovered that the tau protein, thought to be largely responsible for the condition of Alzheimer’s disease in the human brain, travels along neurons and is able to jump from cell to cell.

The research was done using transgenic mice which has worked as an effective model in previous studies. As a result of these findings, some researchers suggest that they key to treating both early onset and later variant Alzheimer’s will be to identify and isolate the illness as early as possible. In other words, identify the location of the tau proteins and then target them for treatment.

In this way, Alzheimer’s treatment may become similar to cancer treatment which aims to identify the location of the tumor and either excise or radiate it in order to remove the disease. Just as in healing carcinomas, the key is to eliminate the threat before the metastasis which involved spreading to other parts of the body.

Previous studies have also shown that the fibrous tangles of tau proteins often begin in the entorhinal cortex. This makes sense from an anatomical perspective as it is this area of the brain that is responsible for processing memories.

As the disease progresses, higher functioning brain cortices are involved which ultimately leads to the fatal nature of the disease. So, in the future we may see that Alzheimer’s disease is treated and cured by simply treating this one small area of the brain. Further research will of course be continued, but the early results are filled with promise.

Posted in Alzheimer's, medical, research | Leave a comment

Strokes in Sickle Cell Children Can Go Undiagnosed

Here’s a good article on the silent stroke phenomenon observed in children with sickle cell anemia.

Strokes aren’t generally something we think about in children, and to be fair, they are unusual, which is why when they do happen they often go undetected and undiagnosed.

“A team of researchers from more than a dozen hospitals and universities have demonstrated that high blood pressure and anemia together put children with sickle cell disease (SCD) at serious danger for symptomless or “silent” strokes. Either condition alone also signaled high risk (Blood, online, Nov. 17, 2011).”

High blood pressure can be seen in children suffering from all kinds of medical issues, as well as just from genetics.

While regular checkups can go a long way toward diagnosing these sorts of risk factors, the sad truth is that many kids just don’t get the consistent medical care they need.

Sickle Cell Disease makes the issue all the more critical, as these children can suffer from a deadly combination of anemia (low red blood cell count), high blood pressure, and clotting that can lead to stroke. From the article,

“Extremely rare in children overall, stroke is a common neurologic complication in children with SCD, a genetic disorder marked by the “sickling,” or bending, of red blood cells that store and distribute oxygen in the body. The misshapen blood cells cause anemia and clog tiny blood vessels, causing pain, tissue damage and stroke. Ischemic stroke is the predominant type of brain injury in children with SCD.”

To learn more about the study, please visit the following link:

http://speech-language-pathology-audiology.advanceweb.com/Features/Articles/Silent-Strokes-in-Children.aspx

Posted in development, medical, research | Leave a comment

Academic Research Should Be Visible to All

Recently I got to wondering how it is that in the United States, where much of our tax dollars end up paying for various forms of research, those studies are not available to the general public in the form of published results.

Each year, the National Institutes of Health and various other similar governmental agencies dole out thousands and thousands in grant money across the country, to research institutions as well as universities, private facilities, and more. In turn, with the money they’re given, these research laboratories put together remarkable studies advancing knowledge in whichever field they specialize in.

However, in order to truly advance the field one must be able to share the data with other organizations.

How is this done? Through publications of course. Ah yes, publications, the bane and thrill of every professor. Publish or perish as the saying goes. So, after a rigorous review process (assuming the journal to which the research is submitted is a good one), the study finally gets published and readers learn the results of the experiment.

Now, if you’ve stuck with me thus far you might know what is coming next. The problem with this system is that only a select few have access to those journals. The author and those in a similar field may or may not subscribe to the journal.

Then there are the libraries of the major research facilities, who shell out tens of thousands or even hundreds of thousands (no exaggeration!) to have electronic access to these articles. It all seems like a bit much when you consider that the original work was funded by money that came from the American people.

Here’s a great article that sums things up better than I could ever hope. Please take a look and see what you think.

Locked in the Ivory Tower

Posted in online resources, research, teacher collaboration | Leave a comment

Surgeons Implant Trachea Made From Man’s Own Cells

This is an amazing story of how doctors in Sweden were able to operate on a patient suffering from tracheal cancer. Previously, the man was told his cancer was inoperable and he was facing certain death. Through the use of stem cells, doctors were able to create a trachea of his own cells which was subsequently implanted. Although the patient is now out of the hospital and back at home, it is likely he will face further complications down the road. Regardless of that, having a second chance at life simply can’t be dismissed.

While the procedure was performed in Sweden, it seems that it will be some time before this procedure is available in the United States. Furthermore, this is only the second time the operation has been completed, and previously used artificial tissue samples. Still, the news is encouraging and we’ll continue to monitor the progress of this exciting development in medicine.

http://www.nytimes.com/2012/01/13/health/research/surgeons-transplant-synthetic-trachea-in-baltimore-man.html

Posted in medical, popular culture, treatment | Leave a comment

Dual Language Immersion Programs

As readers of this site are likely aware, there are a myriad of reasons to support multiple language exposure to children. Regardless of the politically correct talking points that threaten to derail this debate, the scientific evidence is very clear cut and extremely clear. Language exposure in children leads to improvement across the board. Children who experience this environment are basically being treated to a huge educational advantage that provides a lifelong benefit.

The state of California in the United States provides an excellent crucible for measuring some of this change. For many years, public elementary school children were taught using some form of bilingual education. This meant that students would be exposed to both English and a second language as well, often assumed to be Spanish but in fact many other languages as well. As it turned out, these children learned at a quick rate and displayed marked improvement in English even as they were being taught in foreign languages. Due in no small part to political pressures however, California phased out bilingual education.

Now, in present day California, many children have been placed in language immersion courses. In this instance, a child may spend all day learning in a foreign tongue. There are multiple applications of this practice; for example, some children of immigrants may learn the language of their ancestors this way, while other kids gain exposure to a language and culture they never would have found otherwise. What is remarkable about these programs is that they appear to provide benefit to children in their English skills as well – even though they are not being taught in English.

Diversity in these classes have grown, both socioeconomically as well as culturally, but the programs are not without risks or detractors. While evidence does suggest long term gains for those enrolled in the coursework, it is not at all uncommon for children to struggle early on with both languages. As such, it requires a strong commitment from the family involved, and a student willing to put up with the momentary frustration of not being able to communicate effectively.

To read more about Dual Language Immersion Programs, check out the link below. This is a truly fascinating study that cannot be covered in just a few scant paragraphs.

http://www.latimes.com/news/local/la-me-bilingual-20110508,0,3841220.story

Posted in bilingualism, development, language | Leave a comment

Foreign Accent Syndrome

Today, we cover a fascinating topic known to Speech Language Pathologists, but maybe not so much to the common man. Foreign Accent Syndrome is to be sure, a rare disease, but one that once you’ve read about it (or even experienced it if you’re exceptionally lucky), you’ll not soon forget. As an interesting case study, consider the story of Karen Butler. Ms. Butler went in for dental surgery and came out with a foreign accent. Far from a practical joke or a laughing matter, Foreign Accent Syndrome, or FAS, is a sign of brain damage.

Adding to the mystery, Ms. Butler has never visited or lived in the countries who’s accent she’s now exhibiting. Described as a mix of English, Irish and other European accents, the symptoms began almost immediately after awakening from general anesthesia. So how rare is it? According to one well respected neurologist, the number of proven and documented cases number only into the hundreds.

While a major stroke or traumatic brain injury will leave more symptoms than just FAS, it is possible that in Ms. Butler, she suffered a ‘mini-stroke’. Without good imaging, such as an MRI, it is difficult to tell. The smaller the degree of injury the brain has incurred, the more difficult it becomes to identify on any diagnostic test. In cases such as these, it also helps to have a brain scan available from before the accident, for purposes of comparison.

In Ms. Butler’s case, her most likely alternative for a positive outcome will be intensive speech therapy. The likelihood is that with proper treatment, she will be able to return to her normal style, manner, and accent of speaking. Of note, however, is that because FAS is so rare, there is not a great deal of data available to explain how best to go about treatment. As for Ms. Butler herself, she apparently is quite comfortable with her new accent, and has thus far not shown any desire to begin treatment. As such, the world of research will have to wait for the next victim of FAS to step forward in order to truly evaluate treatment techniques.

Posted in accent, language, research | Leave a comment

Developmental Disabilities in American Children

Big news from the Centers for Disease Control today, as they announced a new report stating that fifteen out of every hundred American children suffer from some sort of developmental disability, including autism and attention deficit hyperactivity disorder. The results are based on a survey conducted last year, which depends on parents providing accurate information to come to valid conclusions. Due to the methodology, the report has been ripe for sniping critics, who claim biased subjects like the parents will give unscientific responses.

Of major significance in the report is the increase in autistic cases. It’s no surprise that the autism numbers have risen, as they seemingly do every year, but given the recent political firestorms have surrounded the disease, it makes the study even more contentious. Already enflamed tempers from the great vaccine debate mean that skeptical parents are more likely to view the CDC as a questionable resource rather than the authority many believe it to be. Per the report, autism rates rose from .02 percent to .07 percent, an over 200% increase. Additionally, ADHD children rose from 5.7 to 7.6 percent, with boys receiving the diagnosis twice as often as their female counterparts.

Of central debate is the source of the increase in autistic cases. To this point, there has been no conclusive evidence suggesting any correlation between administration of vaccines and incidence of autism. However, due to various health repercussions that have resulted in other illnesses, skittish parents have begun to question the risks involved. Scientists and doctors associated with the CDC are quick to assure all that the vaccines are indeed necessary, and that the potential negative consequences of failing to insure adequate vaccinations far outweigh the risk of potential side effects or adverse reactions. Of course, when your child becomes the statistical anomaly, the numbers go out the window.

For further reading, make sure to view the latest edition of Pediatrics, where you can find out more about the methodology, results, and conclusions of the contributing scientists.

Posted in ADHD, attention deficit, autism, development, hyperactivity, research | Leave a comment

Study Links Autism to Obesity and Diabetes in Mothers

For years, doctors and medical researchers have known that pregnant mothers are at greater risk for hypertension (high blood pressure), diabetes, and obesity. All of these risk factors are greatly impacted by pregnancy, and these conditions serve to cause great harm to both fetus and mother during gestation, and beyond. Now comes an intriguing study which suggests that in addition to known health problems resulting from these conditions such as stroke, diabetic shock and coma, heart attacks, and other medical problems, children born to these mothers may well be at greater risk of autism.

Researchers at UC Davis have uncovered major differences in the brain development of affected children. Namely, these individuals show an abnormally fast growth rate in the frontal cortex areas of the brain. For years, scientists have observed decreased brain activity coming from these areas in affected individuals, but they now have histological evidence corroborating their findings. Scientists hypothesize that overactive growth rate is responsible for misfires in the neural net, leading to a lack of proper functioning.

Functional MRI scans, or fMRI have shed further light on these findings. Using these techniques, scientists are able to see cross sections of the brain in vivid detail, without causing harm or distress in an individual suffering from autism. Recent advances in medical technology have made it possible to observe brain function on levels never before possible, and may well hold the secret to unraveling even more of autism’s mysteries.

It’s no secret that rates of autism have been rising steadily over the past few decades. While some of this is attributed to better defined diagnosis criteria, and part of it may well be catching children who may have escaped attention in an earlier era, this is not the full explanation. Of course, one should never assume correlation implies causation, but it is interesting that both obesity rates and autism have exploded in prevalence during the same time period.

Posted in autism, development | Leave a comment

Why We Call Obama Osama

If we’re honest, the vast majority of us have done it. For some reason, we have misspoken and said some combination of Osama bin Laden and Barack Obama. But why? It’s not because of some deep seated racism, or a belief that the president of the United States is on par with a global terrorist mastermind. No, the real reason comes down to something far more simple. The words sound the same, yes, but there’s far more to it than that, as linguists and speech language pathologists explain.

The biggest reason is that both words are proper nouns, names, and don’t have strict definitions. Additionally, they are unusual names, at least in our culture. So, it’s not as if confusing Jeff and John. With foreign names, our minds and language centers are not as hard wired to recognize the person. Even when you think of popular names in English, like Emma, David, Christopher, or whatever, you probably have at least a bit of a preconceived notion of what that person would be like, based on your life experience. For names like Obama and Osama, we have no such background and thus no pre-wired language paths.

Another reason for this confusion, according to speech language pathologists, is the intial b in bin Laden’s name. The b can be substituted in his first name, Osama, thus leading to the tongue tangling that ends up as Obama. A b for s substitution is not at all unusual for English speakers. This process is also known as assimilation.

To see all the mistakes made by the media throughout the week, take a look at the Salon article linked below. It’s not just you and me that make this mistake, but some heavy hitters in politics and the press, like Norah O’Donnell of NBC News, Peter Sagal of National Public Radio, and Mitt Romney of the Republican Party. They’re not alone though!

Why we keep calling Obama Osama

Posted in language, popular culture | Leave a comment

Autism Rate May Be Underestimated

A recent study undertaken in South Korea suggests that autism prevalence may be far greater than previously believed. Like many disorders, autism diagnoses are dependent on a number of factors, and individuals with the disease exhibit symptoms along a spectrum. Certainly, in our own experiences, we have all observed higher functioning children and adults with autism, and others that require more assistance.

After analyzing the results of the research, scientists believe that the findings lead to a conclusion which may not be readily obvious to the uneducated observer. To fully understand the findings, we need to take a step back and consider the study itself. Researchers focused on a very small population in South Korea, and studied them in depth for a long period of time. Under this intense scrutiny, scientists found ample evidence of autistic behavior within the study group. Based on the research, the take away is not that autism rates are higher in this particular population, but that if any population was analyzed and studied as closely as this group, similar results would be found.

In other words, autism is all around us, to varying degrees, and is being under represented by diagnoses made hurried and without adequate study. So, while the more heavily afflicted children are caught in the net of treatment and care, better functioning children may be missed entirely by the social safety net. These children then may go on to have difficulty further down the line, whether it be developmental, problems with authority, or other behavioural issues.

These results serve as a good reminder to all of us to consider a number of issues when dealing with children diagnosed with disorders like autism. Namely, these illnesses occur along a spectrum and as such, even though a child has been given a ‘bill of clean health’, it may well be that the diagnosis has been missed. We all should take care to consider these topics, and treat each person as an individual.

Study Suggests Autism Under-Diagnosed

Posted in autism, development | Leave a comment